Measured rollout will tap the drug’s promise while navigating its complex REMS program
Cleveland Clinic will begin offering brexanolone, the first medication to treat moderate to severe postpartum depression, via a pilot program at one of its regional hospitals soon after the drug’s launch, which is expected in late June. The fast-acting neurosteroid, which received FDA approval in March under the name Zulresso™, is administered via continuous IV infusion for 60 hours in an inpatient setting.
As detailed in this earlier Consult QD post, brexanolone is a derivative of endogenous allopregnanolone, a hormone that declines after childbirth. It works as an allosteric modulator of GABA-A receptors. GABA is an inhibitory neurotransmitter and may play an important role in modulating vulnerability to depression and anxiety.
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