ABSTRACT Vibrio cholerae serogroup O1 is responsible for epidemic and pandemic cholera and remains a global public health threat. This organism has been well established as a resident flora of the aquatic environment that alters its phenotypic and genotypic attributes for better adaptation to the environment. To reveal the diversity of clinical isolates of V. cholerae O1 in the Bay of Bengal, we performed whole-genome sequencing of isolates from Kolkata, India, and Dhaka, Bangladesh, collected between 2009 and 2016. Comparison with global isolates by phylogenetic analysis placed the current isolates in two Asian lineages, with lineages 1 and 2 predominant in Dhaka and Kolkata, respectively.

 

 

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Citation: Whole-Genome Analysis of Clinical Vibrio cholerae O1 in Kolkata, India, and Dhaka, Bangladesh, Reveals Two Lineages of Circulating Strains, Indicating Variation in Genomic Attributes Daichi MoritaMasatomo MoritaMunirul AlamAsish K. MukhopadhyayFatema-tuz JohuraMarzia SultanaShirajum MoniraNiyaz AhmedGoutam ChowdhuryShanta DuttaThandavarayan RamamurthyProsenjit SamantaEizo TakahashiKeinosuke OkamotoHidemasa IzumiyaMakoto Ohnishi