Nasal screening for methicillin-resistant Staphylococcus aureus (MRSA) has shown high negative predicative values (NPVs) and therefore may be a powerful stewardship tool for de-escalation and avoidance of empirical therapy, according to results of a retrospective cohort study across Veterans Affairs (VA) medical centers in the United State published in Clinical Infectious Diseases.

The study was performed at VA centers nationwide from 2007 to 2018 and the cohort yielded 561,325 clinical cultures from a variety of anatomical sites. Data from patients with positive result for MRSA on nasal screening upon admission or transfer were obtained from the VA Corporate Data Warehouse. Clinical cultures within 7 days of the swab of the nares were evaluated for the presence of MRSA.


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