Abstract Background Rare tonsillar granulomas may be caused for example by infections, malignancies or sarcoidosis. Granulomas also occur in inborn errors of immunity (IEI) such as common variable immunodeficiency (CVID) with B cell maturation defects and hypogammaglobulinemia. CVID shares various features with sarcoidosis and drug-induced secondary hypogammaglobulinemia; careful consideration of differential diagnosis between these conditions is warranted.
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Citation Laajala, A., Kuismin, O., Tastula, M. et al. Tonsillar granuloma associated with hypogammaglobulinemia. Allergy Asthma Clin Immunol 16, 43 (2020). https://doi.org/10.1186/s13223-020-00441-1