An outbreak of a contagious disease emerges in Caracas, Venezuela. Hospitals are soon at capacity with sick patients. Essential drugs, IVs, PPE, and clinicians are in short supply. Millions of Venezuelans flee to neighboring countries amid a growing crisis and challenges in providing international humanitarian aid. This fictional scenario, part of the Clade X pandemic exercise hosted by the Johns Hopkins Center for Health Security in May 2018, is increasingly exhibiting a disconcerting resemblance to the reality in Venezuela. Thankfully, there have been no signs of a novel respiratory virus like that featured in the Clade X simulation; however, the ongoing political, economic, and humanitarian crisis is very real.