In Brief An analysis of immune cell responses to SARS-CoV-2 from recovered patients identifies the regions of the virus that is targeted and also reveals cross-reactivity with other common circulating coronaviruses Highlights d Measuring immunity to SARS-CoV-2 is key for derstanding COVID-19 and vaccine development d Epitope pools detect CD4+ and CD8+ T cells in 100% and 70% of convalescent COVID patients d T cell responses are focused not only on spike but also on M, N, and other ORFs d T cell reactivity to SARS-CoV-2 epitopes is also detected in non-exposed individuals

 

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