The rogue cellular engine that drives a majority of ovarian cancers remains frustratingly difficult to disable. A new study comparing cancerous tissue with normal fallopian tube samples advances important insights about this machinery and confirms biological hallmarks of survival. High-grade serous carcinoma is the most common type of ovarian cancer, and it has the lowest survival rate. To better understand the disease and its progression, researchers at the U.S. Department of Energy’s Pacific Northwest National Laboratory and their collaborators examined the proteome-;thousands of proteins-;in tissue samples taken from 83 patients around the world. Their results, published in the journal Cell Reports Medicine in April, could help identify more targeted treatments.