An international collaboration of infectious disease experts has identified a large group of people who appear to have naturally mounted an immune response to TB, a bacterial infection that is the leading cause of infectious disease death worldwide. Nearly 200 people from 2500 households with active TB were clearly exposed to TB for more than 10 years but the two most reliable tests (TST and IGRA) came back negative on repeated tests.

“Further research is needed, but it seems that either the tests are not sufficiently sensitive to detect a low-level case of TB or some people are mounting a natural defense, which is what we believe is happening,” said W. Henry Boom, MD, Division Chief of Infectious Disease and HIV Medicine at University Hospitals (UH) Cleveland Medical Center and Case Western Reserve University (CWRU) School of Medicine.

 

Ashashyou [CC0], from Wikimedia Commons

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