Background In contemporary management of chronic obstructive pulmonary disease (COPD), the frequent exacerbator phenotype, based on a 12-month history of acute exacerbation of COPD (AECOPD), is a major determinant of therapeutic recommendations. However, there is considerable debate as to the stability of this phenotype over time.

 

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Citation: Mohsen SadatsafaviJames McCormackJohn PetkauLarry D. LyndTae Yoon LeeDon D. Sin