A new report from Public Health England (PHE) shows an increase in antibiotic-resistant infections in England, despite a decline in antibiotic consumption.

According to PHE’s latest English Surveillance Programme for Antimicrobial Utilisation and Resistance (ESPAUR) report, there were an estimated 60,788 antibiotic-resistant infections in England in 2018, a 9% increase from 2017, when 55,812 drug-resistant infections were reported. That’s the equivalent of 165 new antibiotic-resistant infections every day.

The ESPAUR report also found that the number of bloodstream infections caused by seven priority bacterial pathogens rose by 15,000 from 2014 through 2018, an increase of 21%. And the number antibiotic-resistant bloodstream infections grew by more than 4,100—an increase of 32%—over that period.

In particular, increased resistance to ciprofloxacin and third-generation cephalosporins in Escherichia coli—the most common cause of bloodstream infections in England—and Klebsiella pneumoniae were noted. That increase was associated with increased use of cephalosporin and quinolone antibiotics.

Also of note is an increase in the detection of the most dangerous antibiotic-resistant pathogens, carbapenemase-producing Enterobacteriaceae (CPE), which rose from 72 isolates in 2009 to 4,028 in 2018. An analysis of 202 CPE infections identified between 2015 and 2019 found a 30-day mortality rate of 23.8%.

Credit: CDC

Antibiotic consumption falling

Read more at CIDRAP…