Influenza viral antigens may undergo adaptive mutations during egg-based vaccine production. In the 2017-2018 influenza season, quadrivalent ccIIV (ccIIV4) vaccine was produced using an A(H3N2) seed virus propagated exclusively in cell culture, thus lacking egg adaptive changes. This study aimed to estimate the relative vaccine effectiveness (rVE) of ccIIV4 versus egg-derived quadrivalent vaccines (egg-derived IIV4) in 2017-2018 in the US.



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Citation Constantina Boikos, Gregg C Sylvester, John S Sampalis, James A Mansi, Relative Effectiveness of the Cell-Cultured Quadrivalent Influenza Vaccine Compared to Standard, Egg-Derived Quadrivalent Influenza Vaccines in Preventing Influenza-Like Illness in 2017-2018, Clinical Infectious Diseases, ,