Mechanisms underlying adverse birth and later in life health effects from exposure to air pollution during the prenatal period have not been not fully elucidated, especially in the context of mixtures. We assessed the effects of prenatal exposure to mixtures of air pollutants of particulate matter (PM), PM2.5, PM10, nitrogen oxides, NO2, NOx, ultrafine particles (UFP), and oxidative potential (OP) of PM2.5 on infant birthweight in four European birth cohorts and the mechanistic underpinnings through cross-omics of metabolites and inflammatory proteins.

 

 

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Citation: Jessica E. Laine, Barbara Bodinier, Oliver Robinson, Michelle Plusquin, Augustin Scalbert, Pekka Keski-Rahkonen, Nivonirina Robinot, Roel Vermeulen, Costanza Pizzi, Federica Asta, Tim Nawrot, John Gulliver, Leda Chatzi, Manolis Kogevinas, Mark Nieuwenhuijsen, Jordi Sunyer, Martine Vrijheid, Marc Chadeau-Hyam, and Paolo Vineis Environmental Science & Technology 2020 54 (22), 14502-14513 DOI: 10.1021/acs.est.0c02657