A drug that suppresses appetite has led to some people losing more than a fifth of their body weight, a major international trial shows. A weekly injection of the drug, semaglutide, was given alongside advice on diet and fitness. The study, conducted on almost 2,000 people, showed an average 15kg weight loss during the 15-month trial. Scientists said the results could mark a “new era” in treating obesity with even more therapies on the horizon. Jan, from Kent, lost 28kg (four stone), equivalent to more than a fifth of her body weight. “The drug changed my life and completely altered my approach to food,” she said. She said dieting had made her “miserable” but taking the drug was completely different as she was less hungry.