Understanding the role of nitric oxide and hyaluronan in asthma

Nitric oxide (NO) is a biomarker of airway inflammation in asthma and an indicator of progressing disease. Studies have shown that asthmatics with high levels of exhaled NO have greater airway inflammation and airway reactivity. However, very little is known about the potential role of NO in driving airway inflammation.

In their latest study published in the July 2018 issue of PLOS One, Mark A. Aronica, MD, from Cleveland Clinic’s Department of Allergy and Clinical Immunology, and his team of collaborators investigated the association between NO-modulated hyaluronan (HA) production and inflammation in asthma.

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