In recent years, giant viruses have been unearthed in several of the world’s most mysterious locations, from the thawing permafrost of Siberia to locations unknown beneath the Antarctic ice. But don’t worry, “The Thing” is still a work of science fiction. For now. In a new study, a team of Michigan State University scientists shed light on these enigmatic, yet captivating giant microbes and key aspects of the process by which they infect cells. With the help of cutting-edge imaging technologies, this study developed a reliable model for studying giant viruses and is the first to identify and characterize several key proteins responsible for orchestrating infection.