For the second time in May 2020, The Florida Department of Health in Miami-Dade County has reported an additional human case of West Nile virus (WNV) local transmission infection in a Miami-Dade resident. WNV is the leading cause of mosquito-borne disease in the continental United States. It is most commonly spread to people by the bite of an infected mosquito. There are no vaccines to prevent or medications to treat WNV in people. Most people infected with West Nile virus do not feel sick. About 1 in 5 people who are infected develop a fever and other symptoms such as headache, pain, and fatigue. People with mild illness typically recover within about a week with symptomatic treatment. Less than one-percent of infected people develop a serious, sometimes fatal, illness. Symptoms typically appear between two and 14 days after the bite of an infected mosquito. People over the age of 60 and individuals with weakened immune systems are at an increased risk for severe disease.