Abstract Background: Tick-borne encephalitis virus (TBEV) is an important human pathogen that can cause the serious illness tick-borne encephalitis (TBE). Patients with clinical symptoms can suffer from severe meningoencephalitis with sequelae that include cognitive disorders and paralysis. While less than 30% of patients with clinical symptoms develop meningoencephalitis, the number of seropositive individuals in some regions indicates a much higher prevalence of TBEV infections, either with no or subclinical symptoms. The functional relevance of these subclinical TBEV infections and their influence on brain functions, such as learning and memory, has not been investigated so far.
Citation: Cornelius ADA, Hosseini S, Schreier S, Fritzsch D, Weichert L, Michaelsen-Preusse K, Fendt M, Kröger A. Langat virus infection affects hippocampal neuron morphology and function in mice without disease signs. J Neuroinflammation. 2020 Sep 20;17(1):278. doi: 10.1186/s12974-020-01951-w. PMID: 32951602; PMCID: PMC7504599.