Asthma is a common chronic inflammatory disease of the airways, which continues to cause considerable morbidity and unnecessary mortality across the world [12]. The recognition that even mild asthma is associated with airway inflammation led to the early and widespread use of inhaled corticosteroids (ICS) from the 1970s onwards [34], transforming asthma care by significantly reducing severe exacerbations and asthma deaths. However, the persistently high levels of poor asthma control and ongoing asthma deaths in the 21st century are a growing concern [56] and we believe the widespread use and overuse of short-acting beta-agonist (SABA) inhalers are a major part of the problem.

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