The continued global escalation of coronavirus disease 2019 (COVID-19) cases is of particular concern for pregnant and lactating individuals. While many cases of COVID-19 are asymptomatic or relatively mild, recent evidence suggests that pregnant people are at increased risk of hospitalization and have a 3-fold adjusted relative risk of needing intensive care (10.5 vs 3.9/1000 cases) and mechanical ventilation (2.9 vs 1.1/1000 cases) compared with age-matched nonpregnant individuals.1 Pregnant people with laboratory-confirmed severe or critical COVID-19 disease have higher adjusted relative risks of cesarean delivery (1.57 [95% CI, 1.30-1.90]), postpartum hemorrhage (2.04 [95% CI, 1.19-3.47]), hypertensive disorders of pregnancy (1.64 [95% CI, 1.21-2.23]), and preterm birth (3.53 [95% CI, 2.42-5.15]).2


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Citation: Bianchi DW, Kaeser L, Cernich AN. Involving Pregnant Individuals in Clinical Research on COVID-19 Vaccines. JAMA. Published online February 10, 2021. doi:10.1001/jama.2021.1865