•    We report INICC device-associated module data of 45 countries from 2012-2015.
•    We collected prospective data from 532,483 patients in 523 ICUs for 2,197,304 days.
•    DA-HAI rates and bacterial resistance were higher in INICC ICUs than in CDC-NHSN’s.
•    Device utilization ratio in the INICC ICUs was similar to CDC-NHSN’s.

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