Findings from a prospective cohort study of healthy infants suggested that colonization with toxigenic Clostridioides difficile, or TCD, triggers an immune response against the toxins, providing “natural immunization.”

Larry K. Kociolek, MD, MSCI, assistant professor of pediatrics at the Northwestern University Feinberg School of Medicine, told Infectious Diseases in Children that C. difficile infection (CDI) is much more common in adults compared with children. However, the prevalence of infection is increasing among children.

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