Abstract In April 2020, there were significant reductions in prescription fills of each of the 10 most prescribed outpatient antibiotics in the United States. Monthly azithromycin, amoxicillin-clavulanate, and levofloxacin fills did not rebound significantly from April through July 2020. Coronavirus disease 2019 had an immediate and sustained impact on US outpatient antibiotic prescribing. There are limited nationwide data on the impact of the coronavirus disease 2019 (COVID-19) pandemic on antibiotic prescribing. In the United States (US), most antibiotic prescriptions are filled in outpatient settings [1]. A recent study estimated that US outpatient amoxicillin and azithromycin prescription fills were 64% and 63% lower, respectively, for April 19–26, 2020, than in the same week in 2019 [2]. However, this study did not account for long-term prepandemic trends or prescriptions after April 2020. Our objectives were to measure the impact of COVID-19 on outpatient prescribing of the 10 most commonly filled antibiotic agents in the US through July 2020 and to compare trends with those from before the pandemic.



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Citation: Deanna J Buehrle, M Hong Nguyen, Marilyn M Wagener, Cornelius J Clancy, Impact of the Coronavirus Disease 2019 Pandemic on Outpatient Antibiotic Prescriptions in the United States, Open Forum Infectious Diseases, Volume 7, Issue 12, December 2020, ofaa575, https://doi.org/10.1093/ofid/ofaa575