ABSTRACT Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 185 COVID-19 cases, including 41 cases at ≥6 months post-infection. Spike IgG was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month. SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months. By studying antibody, memory B cell, CD4+ T cell, and CD8+ T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.




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Citation: Jennifer M. DanJose MateusYu KatoKathryn M. HastieCaterina E. FalitiSydney I. RamirezApril FrazierEsther Dawen YuAlba GrifoniStephen A. RawlingsBjoern PetersFlorian KrammerViviana SimonErica Ollmann SaphireDavey M. SmithDaniela WeiskopfAlessandro SetteShane Crotty