Until now, scientists had assumed that there are about 80 so-called open reading frames (ORFs) in the genome of herpes simplex virus 1 (HSV-1). These are the locations in the genome where the information in the DNA is read and translated into proteins. It is now clear that there are a lot more – namely 284 ORFs. These are translated from hundreds of novel viral transcripts, which have now also been identified. This is what research groups from Julius-Maximilians-Universität (JMU) Würzburg in Bavaria, Germany, and other institutions report in the journal Nature Communications.