Highlights

•    A high variability in glycemic response to exercise in subjects with prediabetes exists
•    Responders and non-responders exhibit differential alterations of the gut microbiota
•    Gut microbiota from responders confers the metabolic benefits of exercise in mice
•    Baseline microbiome features accurately predict personalized exercise responses

Exercise is an effective strategy for diabetes management but is limited by the phenomenon of exercise resistance (i.e., the lack of or the adverse response to exercise on metabolic health).

 

Credit: iStock, Mladen Zivkovic

Smiling senior man with weight at gym. Looking at camera.

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