Inhibiting the gene could slow the obesity epidemic

Research from the laboratory of Paul Fox, PhD, Department of Cellular and Molecular Medicine, showed for the first time that inhibiting the enzyme glutamyl-prolyl tRNA synthetase (EPRS) reduces obesity and extends the lifespan of mice, even when fed a high-fat diet.

“For the first time in human history, obesity is a bigger problem in the world than undernourishment, and it’s affecting our health and lifespan. We are excited about this new connection that provides a potential target for treatments to combat obesity and aging,” says Dr. Fox.

This landmark research is published in the journal Nature.

A serendipitous discovery

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Overweight Man Measuring His Belly with tape measure

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