Asingle fecal microbiota transplant (FMT) cured nearly all patients with Clostridioides difficile infection (CDI) in a study published in Gastroenterology. The study reported outcomes from the first 259 pediatric and adult patients at 20 North American clinics enrolled in the FMT National Registry. Participants, for whom standard anti-CDI therapy had failed, mostly had moderate or mild CDI with a median duration of 20 weeks. At the 30-day follow-up for 222 participants, 90% were cured; among them, 98% required only a single FMT. Forty-five percent of participants reported post-FMT symptoms, including diarrhea, abdominal pain, bloating, and constipation, and 6% of symptoms were severe. Three hospitalizations and 2 infections were possibly related to the FMT procedure.


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Citation: Slomski A. Fecal Transplant for Clostridioides difficile Effective in Practice. JAMA. 2020;324(20):2020. doi:10.1001/jama.2020.22572