Question  Among patients with recent myocardial infarction or hospitalization for heart failure, is high-dose trivalent inactivated influenza vaccine more effective than standard-dose quadrivalent inactivated influenza vaccine for reducing all-cause mortality or hospitalizations for cardiac or pulmonary causes? Findings  In this randomized clinical trial that involved 5260 adults and was conducted over 3 influenza seasons, there was no significant difference in the time to first occurrence of all-cause death or cardiopulmonary hospitalization during each enrolling season for those in the high-dose group vs the standard-dose group (hazard ratio, 1.06). Meaning  In patients with high-risk cardiovascular disease, high-dose trivalent influenza vaccine, compared with standard-dose quadrivalent vaccine, did not significantly reduce all-cause mortality or hospitalizations for cardiac or pulmonary causes; influenza vaccination remains strongly recommended in this population.


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Citation: Vardeny O, Kim K, Udell JA, et al. Effect of High-Dose Trivalent vs Standard-Dose Quadrivalent Influenza Vaccine on Mortality or Cardiopulmonary Hospitalization in Patients With High-risk Cardiovascular DiseaseA Randomized Clinical TrialJAMA. Published online December 04, 2020. doi:10.1001/jama.2020.23649