Background COVID-19 associated pulmonary aspergillosis (CAPA) occurs in critically ill COVID-19 patients. Risks and outcomes remain poorly understood. Methods A retrospective cohort study of adult mechanically ventilated COVID-19 patients admitted to five Johns Hopkins hospitals was conducted between March and August 2020. CAPA was defined using composite clinical criteria. Fine and Gray competing risks regression was used to analyze clinical outcomes and multilevel mixed-effects ordinal logistic regression was used to compare longitudinal disease severity scores.

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Citation: Nitipong Permpalung, MD, MPH, Teresa Po-Yu Chiang, MD, MPH, Allan B Massie, PhD, Sean X Zhang, MD, PhD, Robin K Avery, MD, Saman Nematollahi, MD, Darin Ostrander, PhD, Dorry L Segev, MD, PhD, Kieren A Marr, MD, MBA, COVID-19 Associated Pulmonary Aspergillosis in Mechanically Ventilated Patients, Clinical Infectious Diseases, 2021;, ciab223, https://doi.org/10.1093/cid/ciab223