In January 2020, the World Health Organization announced a Chinese outbreak of a respiratory illness caused by a novel coronavirus. Since that time the COVID-19 pandemic has caused more than 38 000 000 infections and 1 000 000 deaths worldwide , with no end yet in sight. This has been paralleled by an explosion of the biomedical literature relating to SARS-CoV-2 and COVID-19, with more than 64 000 papers at the time of this writing. Clinical Infectious Diseases has received a considerable share of these manuscripts, with over 4500 COVID-19-related papers submitted to the journal in the first nine months of 2020, representing more than the total number of submissions the journal ordinarily receives in an entire year, and more than 500 papers published thus far. Clinicians and researchers battling SARS-CoV-2 are finding it challenging to surf the COVID literature tsunami. In this overview, the CID Editors distill several of the most important and surprising lessons that they have learned thus far during the pandemic (Table 1) and identify some of the most important unanswered questions moving forward (Table 2).