Abstract Melioidosis, caused by the Gram-negative bacterium Burkholderia pseudomallei, is a major cause of sepsis and mortality in endemic regions of Southeast Asia and Northern Australia. Bpseudomallei is a potential bioterrorism agent due to its high infectivity, especially via inhalation, and its inherent resistance to antimicrobials. There is currently no vaccine for melioidosis and antibiotic treatment can fail due to innate drug resistance, delayed diagnosis and treatment, or insufficient duration of treatment.

 

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Citation: Trevino SR, Dankmeyer JL, Fetterer DP, Klimko CP, Raymond JLW, Moreau AM, et al. (2021) Comparative virulence of three different strains of Burkholderia pseudomallei in an aerosol non-human primate model. PLoS Negl Trop Dis 15(2): e0009125. https://doi.org/10.1371/journal.pntd.0009125