The results of a randomized clinical trial conducted in the United Kingdom indicate that gentamicin is not a suitable alternative for ceftriaxone as part of first-line treatment for gonorrhea.

But gentamicin combined with azithromycin might be appropriate for treating genital gonorrhea or patients who are allergic to ceftriaxone or have a ceftriaxone-resistant infection, a team of British investigators reported in The Lancet.

The results also call into question the continuing use of azithromycin as part of the dual-therapy regimen.

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