Risk factors for SARS-CoV-2 among patients in the Oxford Royal College of General Practitioners Research and Surveillance Centre primary care network: a cross-sectional study

By |2020-05-31T05:02:11+00:00May 31st, 2020|

Summary Background There are few primary care studies of the COVID-19 pandemic. We aimed to identify demographic and clinical risk factors for testing positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within the Oxford Royal College of General Practitioners (RCGP) Research and Surveillance Centre primary care network. Methods We analysed routinely collected, pseudonymised data [...]

CARB-X FUNDS FACILE THERAPEUTICS TO DEVELOP A NEW TREATMENT TO PREVENT RECURRING C. DIFFICILE BACTERIAL INFECTIONS

By |2020-05-31T04:57:30+00:00May 31st, 2020|

Facile’s new oral drug would disable toxins that enable C. difficile infections to recur (BOSTON) – CARB-X is awarding Facile Therapeutics, based in Belmont, California, USA, up to $1.26 million to develop a new orally bioavailable drug to treat recurring infections caused by Clostridium difficile. Facile could receive up to $17 million more in additional funding from CARB-X [...]

Evidence of prolonged COVID-19 virus shedding noted in China

By |2020-05-31T04:48:34+00:00May 31st, 2020|

Patients with COVID-19 outside of Wuhan, China, shed virus RNA for a median of 17 days, according to a retrospective cohort study published yesterday in the International Journal of Infectious Diseases. Also, a study in the same journal found that third-generation transmission of the COVID-19 epidemic likely began on Jan 17 to 20 in Wuhan, then spread to the rest [...]

US COVID-19 deaths pass 90,000 as Moderna vaccine delivers promising phase 1 results

By |2020-05-31T04:21:45+00:00May 31st, 2020|

Moderna's COVID-19 vaccine candidate appears safe for human use, the company said today as it released results from the phase 1 trial of mRNA-1273. The dose-dependent trial sets the stage for a phase 2 trial, expected to start shortly and a larger phase 3 trial which will begin in July. The phase 1 trail showed an immune [...]

World Health Assembly opens amid pandemic tensions, calls for probe

By |2020-05-31T03:58:57+00:00May 31st, 2020|

Calls for investigations into the World Health Organization (WHO) role in responding to the COVID-19 pandemic and a probe into the source of the virus in China dominated the opening of the World Health Assembly (WHA) today, held virtually and shortened to 2 days. Meanwhile, the global total passed 4.75 million cases today, with deaths reaching [...]

The airborne lifetime of small speech droplets and their potential importance in SARS-CoV-2 transmission

By |2020-05-31T03:34:31+00:00May 31st, 2020|

Abstract Speech droplets generated by asymptomatic carriers of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are increasingly considered to be a likely mode of disease transmission. Highly sensitive laser light scattering observations have revealed that loud speech can emit thousands of oral fluid droplets per second. In a closed, stagnant air environment, they disappear from the [...]

Indoor Particulate Matter during HOMEChem: Concentrations, Size Distributions, and Exposures

By |2020-05-31T03:31:15+00:00May 31st, 2020|

It is important to improve our understanding of exposure to particulate matter (PM) in residences because of associated health risks. The HOMEChem campaign was conducted to investigate indoor chemistry in a manufactured test house during prescribed everyday activities, such as cooking, cleaning, and opening doors and windows. This paper focuses on measured size distributions of [...]

Repurposing Drugs in Oncology (ReDO)—chloroquine and hydroxychloroquine as anti-cancer agents

By |2020-05-31T03:08:25+00:00May 31st, 2020|

Abstract Chloroquine (CQ) and hydroxychloroquine (HCQ) are well-known 4-aminoquinoline antimalarial agents. Scientific evidence also supports the use of CQ and HCQ in the treatment of cancer. Overall, preclinical studies support CQ and HCQ use in anti-cancer therapy, especially in combination with conventional anti-cancer treatments since they are able to sensitise tumour cells to a variety [...]

Anthropometric, Cardiopulmonary and Metabolic Benefits of the High-Intensity Interval Training Versus Moderate, Low-Intensity or Control for Type 2 Diabetes: Systematic Review and Meta-Analysis

By |2020-05-31T03:02:36+00:00May 31st, 2020|

Abstract This study aims to evaluate the effectiveness of high-intensity interval training compared with no intervention and other types of training interventions for people with Type 2 diabetes. A systematic review and meta-analysis of randomized controlled trials that used high-interval intensity training to improve anthropometric, cardiopulmonary and metabolic conditions were conducted. The search was performed [...]

Two faces of the same coin: a qualitative study of patients’ and carers’ coexistence with chronic breathlessness associated with chronic obstructive pulmonary disease (COPD)

By |2020-05-31T02:55:13+00:00May 31st, 2020|

Background Chronic breathlessness is a recognized clinical syndrome that severely impacts patients and carers, who become increasingly restricted in their daily activities. Often, patients become reliant on their carers, who are required to provide constant support. Although individual experiences of breathlessness have been previously investigated, there are few studies exploring contemporaneous experiences of breathlessness of the [...]