Two types of medications appear to be culprits

Prior exposure to antibiotics and proton pump inhibitors are associated with an increased risk of acquiring Clostridioides (formerly Clostridium) difficile infection (CDI) among hospitalized children, according to new Cleveland Clinic research.

Additional high-quality epidemiologic studies are needed to validate the results and explore other potential risk factors. But the findings are an important reminder that clinicians should be cautious about prescribing antibiotics and proton pump inhibitors to pediatric inpatients so as to minimize the threat of hospital-acquired CDI, says study coauthor Charles Foster, MD, of Cleveland Clinic Children’s Center for Pediatric Infectious Diseases.

Credit: CDC

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