Key Points

Question  Is a healthy lifestyle associated with lower risk of dementia, regardless of genetic risk?

Findings  In this retrospective cohort study that included 196 383 participants of European ancestry aged at least 60 years without dementia at baseline, participants with a high genetic risk and unfavorable lifestyle score had a statistically significant hazard ratio for incident all-cause dementia of 2.83 compared with participants with a low genetic risk and favorable lifestyle score. A favorable lifestyle was associated with a lower risk of dementia and there was no significant interaction between genetic risk and healthy lifestyle.

Meaning  A healthy lifestyle was associated with lower risk of dementia among participants with low or high genetic risk.

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