A new family of synthetic antibiotics that possess broad anti-Gram-negative antimicrobial activity has been discovered.

Researchers have reported the discovery and characterisation of a new family of synthetic antibiotics that possess broad-spectrum anti-Gram-negative antimicrobial activity.   The research teams were headed by the University of Zurich (UZH) and Polyphor AG, both Switzerland.

“The new antibiotics interact with essential outer membrane proteins in Gram-negative bacteria,” said John Robinson from the UZH Department of Chemistry, who co-led the study. “According to our results, the antibiotics bind to complex fat-like substances called lipopolysaccharides and to BamA, an essential protein of the outer membrane of Gram-negative bacteria.”

Credit: CDC

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