Most folks are aware of the perils of surface contamination as it relates to the transmission of infectious diseases. Contaminated hands touching door knobs, remote controls, furniture and the like are generally well known as potential routes of transmission. Less understood are the variables and manner in which germs can be moved through the air to cause infectious disease. In this entry, we offer up some of the abundant research and studies that show a number of diseases can be spread through the air. It is important that we acknowledge and continue to try to understand the nuances of the airborne transmission of germs. Until we recognize this, we will fall short in attempts to form broad strategies focused on containing diseases.