The ‘Big Three’ are predicted to get bigger. AIDS, TB and malaria are predicted to kill many more in the coming months and years. COVID-19 could potentially double the number of malaria deaths in sub-Saharan Africa in 2020 when compared with 2018. The world could see an additional 6.3 million cases of TB between 2020 and 2025 and an additional 1.4 million TB deaths during that same period. A six-month disruption of antiretroviral (ARV) therapy could lead to more than 500 000 extra deaths from AIDS-related illnesses in sub-Saharan Africa in 2020–2021. These are projections from three mathematical models published recently.