Abstract

Background

Waning of vaccine-induced immunity is considered to play a central role in the re-emergence of mumps among vaccinated young adults. The aim of the present study was to investigate antibody responses and safety of a third dose of measles-mumps-rubella vaccine (MMR-3) in 150 young adults. Antibody levels were related to a surrogate of protection based on pre-outbreak serum antibody levels of persons with (n=31) or without serological evidence of mumps (n=715).

Methods

IgG and virus-neutralizing (FRNT) antibody responses against both the mumps Jeryl Lynn (JL) vaccine and the G outbreak strain were determined, and vaccine safety was evaluated.

 

Credit: iStock, Manjurul

Credit: iStock, Manjurul

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The Journal of Infectious Diseases, jiz188, https://doi.org/10.1093/infdis/jiz188
Published:
23 April 2019