Abstract Recent studies suggest that birth mode (Cesarean section [C-section] or vaginal delivery) is an important event in the initial colonization of the human microbiome and may be associated with long-term health outcomes. We sought to determine the association between a woman’s birth mode and her vaginal microbiota in adulthood. We re-contacted 144 adult women from two U.S. studies and administered a brief survey. Vaginal microbiota was characterized on a single sample by amplicon sequencing of the V3-V4 hypervariable regions of the 16S rRNA gene and clustered into community state types (CSTs). We evaluated the association between birth mode and a CST with low relative abundance of Lactobacillus spp.


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Citation Stennett CA, Dyer TV, He X, Robinson CK, Ravel J, Ghanem KG, et al. (2020) A cross-sectional pilot study of birth mode and vaginal microbiota in reproductive-age women. PLoS ONE 15(4): e0228574. https://doi.org/10.1371/journal.pone.0228574