The National Institutes of Health (NIH) has awarded more than $12 million to Cleveland Clinic researchers to study the critical link between gut microbial pathways and the development of cardiometabolic diseases.
The researchers are led by Stanley Hazen, MD, PhD, Director of the Center for Microbiome and Human Health in Cleveland Clinic’s Lerner Research Institute and Co-Section Head of Preventive Cardiology and Rehabilitation in Cleveland Clinic’s Miller Family Heart & Vascular Institute.
He and his collaborators on this work — J. Mark Brown, PhD; Zeneng Wang, PhD; Adeline (Lynn) Hajjar, DVM, PhD; and Joseph DiDonato, PhD, all of Lerner Research Institute — will explore the concept that gut microbes act as a key endocrine “organ” that converts digested nutrients into chemical signals that function like hormones, creating physiological changes in humans. The researchers will focus on specific novel pathways linked to atherosclerosis, thrombosis and obesity, as well as the participation of specific gut microbe-driven pathways in increased susceptibility to cardiovascular and metabolic diseases.
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