WHO advisers halt Dengvaxia, for now

By | 2018-04-20T09:45:14+00:00 April 20th, 2018|

The World Health Organization's (WHO's) strategic group of experts on immunization (SAGE) announced today that Dengvaxia, the controversial dengue vaccine, should not be used until clinicians can confirm prior dengue infection at the time of administration. A point-of-care test would determine the recipient's dengue status, and only those who have previously had the virus would [...]

Use of next generation sequence to investigate potential novel macrolide resistance mechanisms in a population of Moraxella catarrhalis isolates

By | 2018-04-19T21:27:23+00:00 April 19th, 2018|

Abstract Although previous studies have confirmed that 23S rRNA gene mutation could be responsible for most of macrolide resistance in M. catarrhalis, a recent study suggested otherwise. Next generation sequence based comparative genomics has revolutionized the mining of potential novel drug resistant mechanisms. In this study, two pairs of resistant and susceptible M. catarrhalis isolates with different multilocus [...]

The impact of insertion sequences on bacterial genome plasticity and adaptability

By | 2018-04-19T21:23:18+00:00 April 19th, 2018|

Transposable elements (TE), small mobile genetic elements unable to exist independently of the host genome, were initially believed to be exclusively deleterious genomic parasites. However, it is now clear that they play an important role as bacterial mutagenic agents, enabling the host to adapt to new environmental challenges and to colonize new niches. This review [...]

Colistin and Polymyxin B Susceptibility Testing for Carbapenem-Resistant and mcr-Positive Enterobacteriaceae: Comparison of Sensititre, MicroScan, Vitek 2, and Etest with Broth Microdilution

By | 2018-04-19T21:15:30+00:00 April 19th, 2018|

ABSTRACT Colistin and polymyxin B remain part of the last line of antibiotics for multidrug-resistant Gram-negative bacteria, such as carbapenem-resistant Enterobacteriaceae. Current joint EUCAST-CLSI recommendations are for broth microdilution (BMD) to be performed for MIC testing of colistin. Commercial susceptibility testing methods were evaluated and compared against the reference BMD, using a susceptibility breakpoint of ≤2 [...]

Study Reveals Previously Unmeasured PLABSI Burden in Acute Care Hospital

By | 2018-04-19T21:06:20+00:00 April 19th, 2018|

Although central line-associated blood stream infections (CLABSIs) are estimated by the Centers for Disease Control and Prevention (CDC) to lead to thousands of fatalities on an annual basis, bloodstream infections from peripheral intravenous lines (PIVs) are also a serious issue. Although many PIVs occur each year in the United States, they receive far less attention [...]

Next-Generation Sequence Analysis Reveals Transfer of Methicillin Resistance to a Methicillin-Susceptible Staphylococcus aureus Strain That Subsequently Caused a Methicillin-Resistant Staphylococcus aureus Outbreak: a Descriptive Study

By | 2018-04-19T21:00:07+00:00 April 19th, 2018|

ABSTRACT Resistance to methicillin in Staphylococcus aureus is caused primarily by the mecA gene, which is carried on a mobile genetic element, the staphylococcal cassette chromosome mec (SCCmec). Horizontal transfer of this element is supposed to be an important factor in the emergence of new clones of methicillin-resistant Staphylococcus aureus (MRSA) but has been rarely observed in real time. In 2012, an outbreak [...]

Treatment Options to Address the Threat of Carbapenem-Resistant Enterobacteriaceae

By | 2018-04-19T20:48:05+00:00 April 19th, 2018|

The global emergence of resistant Enterobacteriaceae that produce carbapenemases has furthered the development of serious, difficult-to-treat infections associated with significant morbidity and mortality.1,2 Antimicrobial agents currently used for treatment of infections caused by carbapenem-resistant Enterobacteriaceae (CRE) include carbapenem combinations, polymyxins, fosfomycin, tigecycline, aminoglycosides, ceftazidime–avibactam, and meropenem–vaborbactam. Trials supporting their clinical use are scarce, and many of [...]

What’s driving increases in MSSA BSI and E. coli BSI in England?

By | 2018-04-19T20:40:52+00:00 April 19th, 2018|

I was recently browsing through the HCAI mandatory reporting data in England (as you do) and noticed that the increasing trend in E. coli BSIs and MSSA BSIs seems to be following a similar trajectory. Could the drivers of these two distinctly different organisms be similar? The figure below shows the number of C. difficile infections, E. coli BSIs, MRSA BSIs, and MSSA [...]

Meeting the Challenges of Infection Control in Hemodialysis Facilities

By | 2018-04-19T20:32:01+00:00 April 19th, 2018|

Dialysis is a vital and life-saving measure for millions of individuals around the world suffering from renal failure. End-stage renal disease (ie, kidney failure) impacts more than 660,000 Americans alone, meaning that the availability of dialysis is paramount to their health. Roughly 468,000 of those Americans suffering from end-stage renal disease (ESRD) rely on dialysis to remove toxins, solutes, [...]

Switzerland reports big increase of tularemia in 2017

By | 2018-04-19T20:11:48+00:00 April 19th, 2018|

Health officials in Switzerland have reported a dramatic increase in the bacterial infection, tularemia last year with a growing number of incidents with tick bites has been recorded over the past few years. A Tularemia lesion on the dorsal skin of right hand/CDC According to a Swiss Info report, 130 confirmed cases of tularemia were reported last [...]