Association Between Obesity and Cardiovascular Outcomes A Systematic Review and Meta-analysis of Mendelian Randomization Studies

Key Points

Question  Do mendelian randomization data show that an association exists between obesity and cardiovascular outcomes?

Findings  In this systematic review and meta-analysis of nearly 1 million participants, obesity was associated with type 2 diabetes and coronary artery disease but not with stroke.

Meaning  Obesity may increase the risk of subsequent diabetes and may contribute to cardiovascular outcomes and should thus remain a major focus of public health initiatives.

Abstract

Importance  Although dyslipidemia has been consistently shown to be associated with atherogenesis, an association between obesity and cardiovascular disease outcomes remains controversial. Mendelian randomization can minimize confounding if variables are randomly and equally distributed in the population of interest.

Objective  To assess evidence from mendelian randomization studies to provide a less biased estimate of any association between obesity and cardiovascular outcomes.

Data Sources  Systematic searches of MEDLINE and Scopus from database inception until January 2018, supplemented with manual searches of the included reference lists.

Study Selection  Studies that used mendelian randomization methods to assess the association between any measure of obesity and the incidence of cardiovascular events and those that reported odds ratios (ORs) with 95% CIs estimated using an instrumental variable method were included. The 5 studies included in the final analysis were based on a consensus among 3 authors.

Data Extraction and Synthesis  Two investigators independently extracted study characteristics using a standard form and pooled data using a random-effects model. The Meta-analysis of Observational Studies in Epidemiology (MOOSE) reporting guideline was followed.

Extrasystole On Electrocardiogram Record Paper

Main Outcomes and Measures  Obesity associated with type 2 diabetes, coronary artery disease, or stroke. The hypothesis was formulated prior to data collection.

Results  Of 4660 potentially relevant articles, 2511 titles were screened. Seven studies were included in the systematic review, and 5 studies with 881 692 participants were eligible to be included in the meta-analysis. Pooled estimates revealed that obesity was significantly associated with an increased risk of type 2 diabetes (OR, 1.67; 95% CI, 1.30-2.14; P < .001; I2 = 93%) and coronary artery disease (OR, 1.20; 95% CI, 1.02-1.41; P = .03; I2 = 87%). No association between obesity and stroke was found (OR, 1.02; 95% CI, 0.95-1.09; P = .65; I2 = 0%).

Conclusions and Relevance  The present meta-analysis suggests that obesity is associated with type 2 diabetes and coronary artery disease. Although this analysis of mendelian randomization studies does not prove causality, it is supportive of a causal association. Hence, health care practitioners should continue to emphasize weight reduction to combat coronary artery disease.

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By |2018-11-19T15:31:08+00:00November 19th, 2018|

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